Welcome to the UCLA repository of amyloid diffraction images and analysis tool

• About the server
• Upload a diffraction pattern
• Compare 2 diffraction patterns

Amyloids are linear aggregates of protein that are found in certain disease states such Alzheimer's disease, Huntington's disease and others. Several characteristics are diagnostic for amyloid including unbranches fiber morphology and binding of the particular dyes Congo Red or Thiaflavin T. Perhaps the most important diagnostic feature is a cross-beta diffraction pattern from X-ray diffraction of aligned fibers.

Although many amyloid fibers have been characterized by fiber diffraction, to this point, no one has undertaken a comparative anaylsis of the diffraction characteristics and no single repository exists for all of the diffraction patterns taken of amyloid.

This server converts existing amyloid fiber diffractions to a common scale and deposits the scaled information in an accessible repository in order to allow comparison and analysis of the diffraction patterns.

Upload a diffraction pattern to the server