This page implements the contact prediction method described in:
Using inferred residue contacts to distinguish between correct and incorrect protein models.
Christopher S. Miller and David Eisenberg
Bioinformatics 2008 24(14):1575-1582 (doi:10.1093/bioinformatics/btn248)
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PubMed]
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Bioinformatics OpenAccess]
January 4, 2011: The server is back up again after a change in our cluster software temporarily caused some trouble. As always, please let me know if there are problems via the contact link at upper right.
Notes about multiple sequence alignments
- The sequence for which you would like contact predictions should be the first sequence in your multiple sequence alignment.
- The contact prediction method was tested on multiple sequence alignments built by gathering BLAST homologs with E-value <= 1e-10. We suggest you follow a similar protocol.
- Your alignment will be pre-filtered to remove sequences with > 80% identity to another sequence in the alignment.
Download the source code of the software to run locally here