This page implements the contact prediction method described in:
Using inferred residue contacts to distinguish between correct and incorrect protein models.
Christopher S. Miller and David Eisenberg
Bioinformatics 2008 24(14):1575-1582 (doi:10.1093/bioinformatics/btn248)
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PubMed]
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Bioinformatics OpenAccess]
September 18, 2009: It has come to my attention that a change in hardware had temporarily disabled this web server. It should be running again now. I apologize for any inconvenience. Feel free to contact me if you continue to experience troubles.
Notes about multiple sequence alignments
- The sequence for which you would like contact predictions should be the first sequence in your multiple sequence alignment.
- The contact prediction method was tested on multiple sequence alignments built by gathering BLAST homologs with E-value <= 1e-10. We suggest you follow a similar protocol.
- Your alignment will be pre-filtered to remove sequences with > 80% identity to another sequence in the alignment.
Download the source code of the software to run locally here